無錫真愛健康官網-專注糖尿病營養調理,營養方案個性化定制
咨詢熱線:0510-85730778

Cell子刊:過度運動可能影響血糖控制

創作:vicky: 審核:何才高:
2021-03-24

①11名健康志愿者(5男6女)進行4周的運動訓練,前3周的訓練強度逐漸增加,第4周降低訓練負荷用于恢復;

②*強度的訓練(每周152分鐘的高強度間隔訓練)可導致線粒體功能受損,表現為線粒體呼吸顯著降低及線粒體密度的代償性增加;

③另外,*強度的訓練可導致受試者的葡萄糖耐受量及胰島素分泌水平的顯著降低;

④線粒體功能受損及葡萄糖耐受量降低伴隨著Nrf2的表達降低,后者參與抗氧化防御;

⑤高水平的耐力運動員表現出血糖控制受損。


關鍵詞
主編推薦語
Cell Metabolism上發表的一項*研究,在11名健康志愿者中發現,過度運動可能導致線粒體功能受損,并降低葡萄糖耐受量。另外,在高水平的耐力運動員中也可觀察到血糖控制受損。
延伸導讀

本研究的原文信息和鏈接出處,以及相關解讀和評論文章。歡迎讀者朋友們推薦!
 Cell Metabolism [IF:21.567]
Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers
過度運動訓練造成健康志愿者的線粒體功能受損及葡萄糖耐受降低
10.1016/j.cmet.2021.02.017
03-18, Article
Abstract:
Exercise training positively affects metabolic health through increased mitochondrial oxidative capacity and improved glucose regulation and is the first line of treatment in several metabolic diseases. However, the upper limit of the amount of exercise associated with beneficial therapeutic effects has not been clearly identified. Here, we used a training model with a progressively increasing exercise load during an intervention over 4 weeks. We closely followed changes in glucose tolerance, mitochondrial function and dynamics, physical exercise capacity, and whole-body metabolism. Following the week with the highest exercise load, we found a striking reduction in intrinsic mitochondrial function that coincided with a disturbance in glucose tolerance and insulin secretion. We also assessed continuous blood glucose profiles in world-class endurance athletes and found that they had impaired glucose control compared with a matched control group.

免费黄片网页