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國內團隊:枸杞花青素改善高脂飲食誘導的小鼠腸道屏障功能障礙及腸道炎癥

創作:vicky: 審核:何才高:
2021-03-18

①給高脂飲食小鼠喂食枸杞花青素(AC)12周可減輕體重增加;

②AC可富集產短鏈脂肪酸菌(瘤胃球菌科、擬桿菌屬等)并增加短鏈脂肪酸含量,減少產內毒素菌(如螺桿菌屬和脫硫弧菌科)并降低內毒素(如LPS)水平;

③短鏈脂肪酸可激活G蛋白偶聯受體,抑制組蛋白去乙酰化酶,增加腸道緊密連接mRNA和蛋白表達水平,降低腸道通透性,保護腸道屏障完整性;

④這些作用通過抑制LPS/NF-κB/TLR4通路減輕腸道炎癥。


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主編推薦語
西北農林科技大學的李巨秀團隊與寧夏農林科學院的安巍團隊在Molecular Nutrition and Food Research上發表的一項*研究,給高脂飲食喂養的小鼠補充枸杞花青素12周,劑量分別為每日50、100和200mg/kg體重(相當于人的5.50、10.99和21.99毫克/公斤體重),可通過調節腸道菌群,以誘導短鏈脂肪酸生成并抑制內毒素產生,從而減輕結腸屏障功能障礙和炎癥。
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本研究的原文信息和鏈接出處,以及相關解讀和評論文章。歡迎讀者朋友們推薦!
 Molecular Nutrition and Food Research [IF:5.309]
Lycium ruthenicum anthocyanins attenuate high‐fat diet‐induced colonic barrier dysfunction and inflammation in mice by modulating the gut microbiota
枸杞花青素通過調節腸道菌群減輕高脂肪飲食誘導的小鼠結腸屏障功能障礙和炎癥
10.1002/mnfr.202000745
02-24, Article
Abstract:
Scope: Gut barrier dysfunction and inflammation originating from a dysbiotic gut microbiota (GM) are strongly associated with a high‐fat diet (HFD). Anthocyanins from Lycium ruthenicum (ACs) have shown antiobesity effects through modulating the GM. However, the mechanism linking the antiobesity effects of ACs and GM modulation remains obscure.
Methods and results: To investigate the ameliorative effects of ACs on colonic barrier dysfunction and inflammation, mice were fed an HFD with or without ACs at doses of 50, 100 and 200 mg/kg for 12 weeks. AC supplementation reduced weight gain, enriched short‐chain fatty acid (SCFA)‐producing bacteria (e.g., Ruminococcaceae, Muribaculaceae, Akkermansia, Ruminococcaceae_UCG‐014, and Bacteroides) and SCFA content, depleted endotoxin‐producing bacteria (e.g., Helicobacter and Desulfovibrionaceae), and decreased endotoxin (i.e., lipopolysaccharides) levels. SCFAs substantially activated G protein‐coupled receptors (GPRs), inhibited histone deacetylases (HDAC), increased intestinal tight junction mRNA and protein expression levels, reduced intestinal permeability, and protected intestinal barrier integrity in HFD‐induced mice. These effects mitigated intestinal inflammation by inhibiting the LPS/NF‐κB/TLR4 pathway.
Conclusion: These data indicated that ACs can mitigate colonic barrier dysfunction and inflammation, induce the SCFA production and inhibit endotoxin production by modulating the GM in HFD‐fed mice. This finding provides a clue for understanding the antiobesity effects of ACs.

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