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西安交通大學:維生素C的降壓作用或與腸道菌群調節有關

創作:vicky: 審核:何才高:
2021-03-05

①維生素C(VC)改善高血壓大鼠腸道菌群的多樣性和豐富性,同時顯著降低自發性高血壓大鼠的血壓;

②VC改變腸道菌群的組成和相關生物學功能,恢復腸道代謝和生物合成相關功能,進而改善高血壓大鼠的小腸病理特征和完整性;

③VC可增加絨毛長度和改善腸腔血屏障的完整性從而改善腸道病理,還可減少腸道上皮細胞中的炎性細胞因子;

④VC可減輕高血壓大鼠下丘腦室旁核的炎癥反應和氧化應激。


關鍵詞
主編推薦語
腸道失調和腸-腦軸失調是高血壓的發病機制之一。維生素C是一種常見的膳食補充劑,可以降低高血壓動物的血壓。西安交通大學的李宏寶和康玉明合作在Molecular Nutrition and Food Research上發表文章,發現VC可顯著降低自發性高血壓大鼠的血壓,同時豐富腸道菌群、改善腸道病理和完整性、減少下丘腦室旁核的炎癥反應和氧化應激,表明VC的抗壓功能涉及腸道菌群組成和功能的重塑。
延伸導讀

本研究的原文信息和鏈接出處,以及相關解讀和評論文章。歡迎讀者朋友們推薦!
 Molecular Nutrition and Food Research [IF:5.309]
Altered Gut Microbiota is Involved in the Anti‐Hypertensive Effects of Vitamin C in Spontaneously Hypertensive Rat
自發性高血壓大鼠中,腸道菌群改變與維生素C的降壓作用有關
10.1002/mnfr.202000885
02-06, Article
Abstract:
Scope: Gut dysbiosis and dysregulation of the gut‐brain‐axis contributes to the pathogenesis of hypertension. Vitamin C (VC) is a common dietary supplement that shows the ability to lower the elevated blood pressure in hypertensive animals. Thus, we propose the hypothesis that the gut microbiota is involved in the anti‐hypertensive effect of VC.
Methods and results: We examined the changes of the gut microbiota and pathology in a spontaneously hypertensive rat (SHR) model after daily oral intake of VC in dosage of 200 mg/kg or 1000 mg/kg. After four weeks, the elevated blood pressure of SHRs in both VC‐treated groups were attenuated. Sequencing of the gut microbiota showed improvement in its diversity and abundance. Bioinformatic analysis suggested restored metabolism and biosynthesis related functions of the gut, which were confirmed by the improvement of gut pathology and integrity. Analysis of the hypothalamus paraventricular nucleus (PVN), the central pivot of blood pressure regulation, also showed reduced inflammatory responses and oxidative stress.
Conclusions: The reduced blood pressure, enriched gut microbiota, improved gut pathology and integrity, and reduced inflammatory responses and oxidative stress in the PVN together suggest that the anti‐hypertensive effects of VC involve reshaping of gut microbiota composition and function.

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